Literature Reviews

Medical Literature Reviews

What types of Medical Literature Reviews does HEA provide?

  • Comprehensive Reviews: Our Comprehensive Literature Reviews identify, appraise, and synthesize all high quality evidence relevant to a research question. Our reviews generally focus on the health economic and humanistic impact of an intervention in a specific therapeutic area, the burden of a particular illness, the epidemiology and current clinical practice patterns (i.e., diagnosis and treatment) for a disease, and/or a summary of an unmet medical need. Our Comprehensive Reviews also include abstraction tables for the key evidence (studies) in the review.
  • Expedited Reviews: Our Expedited Reviews provide quick summaries of what is already known about a specific topic, disease area, or intervention. Expedited Reviews use systematic review methods to search and evaluate the literature, but the comprehensiveness of the search and other review stages may be limited.

What are some benefits of performing Medical Literature Reviews?

  • Understand the epidemiology (incidence and prevalence) of a particular disease
  • Quantify the humanistic and economic burden of illness including the direct and indirect costs
  • Evaluate the competitive landscape and limitations of current interventions
  • Guide the design of clinical-economic studies
  • Identify GAPs in the medical literature on the economic, clinical, and humanistic impact for particular interventions
  • Inform the development of health economic evaluations and model parameter estimates

Our Approach

  • Define the Research Question and Conduct Literature Search
  • Select Relevant Studies, Develop Review Protocol, and Assess Study Quality
  • Synthesize the Results and Prepare Report

Our Experience

  • Our medical writers and health economics researchers have performed medical literature reviews on the costs and outcomes of new interventions, the global epidemiology and burden of illness, the direct and indirect costs of disease, and the competitive landscape and limitations of current interventions in a number of therapeutic areas.
  • Some of the therapeutic areas where we have performed medical literature reviews include age-related macular degeneration, atopic dermatitis, chemotherapy induced anemia, chronic migraine, chronic renal insufficiency, diabetic macular edema, obesity, osteoarthritis, overactive bladder, post-operative pain management, and spinal fusion.
  • Our medical literature reviews have been used by our clients to develop an early understanding of disease landscapes, to support regulatory and reimbursement submissions for new interventions, and to help inform evidence generation activities and publication strategies.